ĐỐI CHIẾU ĐẶC ĐIỂM LÂM SÀNG, HÌNH ẢNH HỌC VÀ MÔ BỆNH HỌC Ở BỆNH NHÂN VIÊM MŨI XOANG MẠN TÍNH CÓ POLYP MŨI

Abstract

Objectives: To describe clinical, imaging and histopathological characteristics and to assess the relationship between these findings in patients with chronic rhinosinusitis with nasal polyps. Methods: A descriptive cross-sectional study prospective data was conducted in 38 patients with chronic rhinosinusitis with nasal polyps treated at Thai Nguyen National Hospital, from October 2025 to June 2026. Clinical symptoms, nasal endoscopy, computed tomography and tissue eosinophil density were evaluated. Results: The mean age was 41.82 ± 15.49 years and females accounted for 52.63%. Nasal obstruction, rhinorrhea, facial pain/headache and olfactory dysfunction were observed in 97.37%, 84.21%, 78.95% and 65.79% of patients, respectively. The mean VAS, Lund-Kennedy and Lund-Mackay scores were 8.03 ± 1.03, 7.50 ± 2.11 and 12.84 ± 5.24, respectively. Eosinophil-predominant polyps accounted for 68.42%. Compared with the neutrophil-predominant group, the eosinophil-predominant group had significantly higher VAS, Lund-Kennedy and Lund-Mackay scores. Tissue eosinophil density correlated positively with VAS, Lund-Kennedy and Lund-Mackay scores. Conclusion: Eosinophil-predominant inflammation was common in the study population and was associated with greater clinical and objective disease severity. Tissue eosinophil density correlated particularly with endoscopic and CT disease severity.