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Issue: Vol. 71 No. 77 (2026)
Section: Articles
DOI: 10.60137/tmhvn.v71i77.443
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Tran, P. C. T., Pham, K. H., Le, C. D., Pham, T. C., Lâm, H. T., Lê, T. Q. M., Cao, M. T., Trương, K. T., Hoang, B. D., Tran, T. T. H., Vo, C. M., & Nguyen, X. Q. (2026). EXPERT CONSENSUS ON THE EFFICACY AND SAFETY OF FEXOFENADINE IN THE TREATMENT OF ALLERGIC RHINITIS IN VIETNAM. Vietnam Journal of Otorhinolaryngology - Head and Neck Surgery, 71(77). https://doi.org/10.60137/tmhvn.v71i77.443

EXPERT CONSENSUS ON THE EFFICACY AND SAFETY OF FEXOFENADINE IN THE TREATMENT OF ALLERGIC RHINITIS IN VIETNAM

Phan Chung Thuy Tran1, , Kien Huu Pham2, Cong Dinh Le3, Tuan Canh Pham4, Huyen Tran Lâm4, Tran Quang Minh Lê5, Minh Thanh Cao6, Kim Tri Trương7, Ba Dung Hoang8, Thi Thúy Hang Tran1, Cong Minh Vo9, Xuan Quang Nguyen10
1 Hội Tai Mũi Họng Việt Nam
2 Bệnh viện Đại học Y Dược TP.HCM
3 Bệnh viện Bạch Mai, Hà Nội
4 Bệnh viện Tai Mũi Họng Trung Ương, Hà Nội
5 Bệnh viện, Tai Mũi Họng TP.HCM
6 Bệnh viện Đại học Y Hà Nội
7 Bệnh viện Tai Mũi Họng Sài Gòn
8 Bệnh viện Chợ Rẫy, TP.HCM
9 Bệnh viện Đa khoa Tâm Anh TP.HCM
10 Bệnh viện FV, TP.HCM

Main Article Content

Abstract

Objective: To establish an expert consensus on the efficacy, safety, and clinical role of fexofenadine in the management of allergic rhinitis in Vietnam. Methods: A modified Delphi approach was applied to a panel of Vietnamese otorhinolaryngology specialists based on updated medical evidence from clinical trials and real-world practice surveys. Results: Fexofenadine improves symptoms within 60 min, maintains efficacy for 24 hours, does not impair cognitive or psychomotor functions, and is well tolerated in older adults and children. Conclusion: The expert panel agreed that Fexofenadine should be considered one of the preferred options for allergic rhinitis treatment in Vietnam, particularly in the context of increasing air pollution, the need for sustained treament, and clinical situations in which alertness and safety are essential.

Keywords

Fexofenadine, allergic rhinitis, second-genaration H1-antihistamin, expert consensus

Article Details

References

1. Lâm HT, Tường NV, Ekerljung L, Rönmark E, Lundbäck B. Allergic rhinitis in northern Vietnam: Increased risk of urban living according to a large population survey. Clin Transl Allergy. 2011;1(1):7.
2. Axelrod D, Bielory L. Fexofenadine hydrochloride in the treatment of allergic disease: A review. Journal of Asthma and Allergy, 1, 19-29.
3. Niederberger M, Spranger J. Delphi technique in health sciences: A map. Frontiers in Public Health, 8, Article 457. Front Public Health. 2020;8:457.
4. Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al. GRADE: An emerging consensus on rating quality of evidence and strength of recommendations. BMJ. 2008;336(7650):924-926.
5. Ellis AK, Murrieta-Aguttes M, Furey S, Picard P, Carlsten C. Effect of fexofenadine hydrochloride on allergic rhinitis aggravated by air pollutants. ERJ Open Res. 2021;7(2):00806-2020.
6. Naclerio RM, Ansotegui IJ, Canonica GW, Rouadi PW, Zhang L, Murrieta-Aguttes M. Twenty-five years: The fexofenadine clinical experience. World Allergy Organ J. 2024;17(9):100950.
7. Simons FER. Advances in H1-antihistamines. N Engl J Med. 2004;351(21):2203-2217.
8. Howarth PH, Stern MA, Roi L, Reynolds R, Bousquet J. Double-blind, placebo-controlled study comparing the efficacy and safety of fexofenadine hydrochloride (120 and 180 mg once daily) and cetirizine in seasonal allergic rhinitis. J Allergy Clin Immunol. 1999;104(5):927-933.
9. Gilboa SM, Strickland MJ, Olshan AF, Werler MM, Correa A. Use of antihistamine medications during early pregnancy and isolated major malformations. Birth Defects Res A Clin Mol Teratol. 2009;85(2):137-150.
10. Kamath AV, Yao M, Zhang Y, Chong S. Effect of fruit juices on the oral bioavailability of fexofenadine in humans. J Clin Pharmacol. 2005;45(4):459-466.