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Issue: Vol. 71 No. 76 (2026)
Section: Articles
DOI: 10.60137/tmhvn.v71i76.359
Date Published: 30/06/2026
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Bui, T. K., Vu, N. Q., Vu, D. K., & Pham , V. H. (2026). A SCOPING REVIEW ON THE APPLICATION OF COLD ATMOSPHERIC PLASMA IN WOUND HEALING. Vietnam Journal of Otorhinolaryngology - Head and Neck Surgery, 71(76), 1-8. https://doi.org/10.60137/tmhvn.v71i76.359

A SCOPING REVIEW ON THE APPLICATION OF COLD ATMOSPHERIC PLASMA IN WOUND HEALING

Thi Khanh Bui1, , Ngoc Quynh Vu1, Duc Kenh Vu2, Van Hiep Pham 3
1 Bệnh viện Đại học Y Hà Nội
2 Bệnh viện Y học Cổ truyền TW
3 Bệnh viện Tai Mũi Họng Trung Ương

Main Article Content

Abstract

Objective: To provide an overview of the efficacy, molecular mechanisms, and safety of atmospheric pressure cryotherapy in the treatment of acute and chronic wounds. Methods: A scoping review. Results: Atmospheric pressure cryotherapy promotes wound healing by eliminating drug-resistant bacteria, destroying biofilms, modulating inflammatory cytokines, and activating proliferative signaling pathways such as PI3K/AKT and MAPK via protein kinase CK2. Clinical trials showed that CAP significantly reduced wound area (p<0.0001), decreased wound pH, and improved patient quality of life due to marked pain reduction. Conclusion: Atmospheric pressure cryotherapy is an effective non-invasive treatment for difficult-to-heal wounds, especially diabetic foot ulcers.

Keywords

Cold Atmospheric Plasma, wound healing, diabetic foot ulcer.

Article Details

References

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