KHẢO SÁT CHỈ SỐ BẠCH CẦU ÁI TOAN TRONG MÁU VÀ MÔ POLYP Ở BỆNH NHÂN VIÊM MŨI XOANG MẠN CÓ POLYP MŨI

Abstract

Background: Chronic rhinosinusitis is a common heterogenous disease, affecting 5 - 12% of the general population. Among them, chronic rhinosinusitis with nasal polyps (CRSwNP) accounts for about 25 - 30% of total chronic rhi- nosinusitis. Many studies recently investigated that blood eosinophil index is closely associated with the eosinophils in the nasal polyp tissue as well as with the recurrence ofCRSwNP. This is also one of the factors that contribute to the development of asthma. Consequently, blood eosinophil count may be capable of distinguishing CRSwNP phenotypes. Objective: Survey of blood eosinophil count and eosinophil in nasal polyp tissue of patients with CRSwNP at the Ear Nose Throat Hospital in Ho Chi Minh City. Methods: cross-sectional study. Results: The total of 120 patients were analyzed. Among them, the rate of eosinophilic CRSwNP accounted for 50,8% and the rate of non-eosinophilic CRSwNP was 49,2%. The average age is 45,6 ± 14,4 years old, including 80 males and 40 females. The average preoperative score is 34.02 ± 13.49 points. The preoperative improved Lund Kennedy score is 8.66 ± 2.44 points. The preoperative of Lund - Mackay is 16.68 ± 4.98 points. The count and percentage of blood eosinophils in eosinophilic CRSwNP group were significantly higher than in the non-eosinophilic CRSwNP group. There is a positive correlation between the eosinophil index in blood and in tissues. With a cut-off of0,325 x 109/L blood eosinophil count, the sensitivity is 83,6% and the specificity is 76,3%; with a cut-off of 3,45% blood eosinophil percentage, the sensitivity was 95,1% and the specificity was 71,2%. Conclusion: The blood eosinophil index may be capable of screening for eosinophilic CRSwNP.