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Date Published: 27/01/2025
Online Published: 15/11/2024
Abstract Views: 12
Views PDF: 4
DOI: https://doi.org/10.60137/tmhvn.v69i66.158
Issue
Vol. 69 No. 66
Section
Articles
How to Cite
Nguyen, T. N. M., & Dao, T. D. (2024). INTRATYMPANIC CORTICOID INJECTION FOR SUDDEN SENSORINEURAL HEARING LOSS: A SCOPING REVIEW. Vietnam Journal of Otorhinolaryngology - Head and Neck Surgery, 69(66), 23-31. https://doi.org/10.60137/tmhvn.v69i66.158

INTRATYMPANIC CORTICOID INJECTION FOR SUDDEN SENSORINEURAL HEARING LOSS: A SCOPING REVIEW

Thi Ngoc Mai Nguyen1, , Trung Dung Dao2
1 Trường Đại học Y Dược Thái Nguyên
2 Khoa Tai Mũi Họng, Bệnh viện Bạch Mai; Bộ môn Tai Mũi Họng, Trường Đại học Y Hà Nội

Main Article Content

Abstract

Background: Sudden sensorineural hearing loss (SSNHL) requires emergency medical treatment. This study aimed to review the use of intratympanic corticoid injection in the treatment of SSNHL. Subjects and methods: A literature search was conducted using Pubmed database from January 2018 to December 2023, using the appropriate keywords.
Results: 119 articles were found, in which 20 articles met the inclusion and exclusion criteria were selected. Three types of corticoids used are dexamethasone (4 mg/ml, 5 mg/ml, 10 mg/ml), methylprednisolone (40 mg/ml) and triamcinolone acetonide (40 mg/ml). Treatments included initial therapy (alone, or combined with systemic corticosteroids) and salvage.
Except for the posterosuperior angle, other locations on the tympanic membrane can be used for injection. The commonly applied injection frequency was once a day, and once every 2-4 days; 77.1% had injection duration within 2 weeks. Initial intratympanic injection, alone or combined with systemic corticosteroids and salvage, all resulted in hearing improvement with similar rates. The most common discomforts were otalgia and dizziness/lightheadedness. Conclusion: Intratympanic corticoid injection is an effective treatment method, and is well applied in both initial and salvage regimens.

Keywords

sudden sensorineural hearing loss, intratympanic corticosteroid injection

Article Details

References

1. Chandrasekhar SS, Tsai Do BS, Schwartz SR, et al. Clinical Practice Guideline: Sudden Hearing Loss (Update). Otolaryngol Neck Surg. 2019; 161(1_suppl): S1-S45.
2. Spear SA, Schwartz SR. Intratympanic steroids for sudden sensorineural hearing loss: a systematic review. Otolaryngol Head Neck Surg. 2011;145(4): 534-543.
3. Silverstein H, Choo D, Rosenberg SI, et al. Intratympanic steroid treatment of inner ear disease and tinnitus (preliminary report). Ear Nose Throat J. 1996;75(8): 468-471.
4. Wilson WR, Byl FM, Laird N. The Efficacy of Steroids in the Treatment of Idiopathic Sudden Hearing Loss: A Double-blind Clinical Study. Arch Otolaryngol - Head Neck Surg. 1980;106(12): 772-776.
5. Haynes D.S, Malley M.O, Cohen S, et al. “Intratympanic dexamethasone for Sudden Sensorineural Hearing Loss after Failure Systemic Therapy”, Laryngoscope, 2007; (117), pp. 3-5.
6. Parnes LS et al. “Corticoid pharmacokinetics in the inner ear: an animal study followed by clinical application”. Laryngoscope; 1999; 109: 1-17.
7. Si Y, Jiang HL, Chen YB, et al. Round Window Niche Drilling with Intratympanic Steroid Is a Salvage Therapy of Sudden Hearing Loss. Audiol Neurootol. 2018; 23(6):309-315.
8. Yang J, Wu H, Zhang P, et al. The pharmacokinetic profiles of dexamethasone and methylprednisolone concentration in perilymph and plasma following systemic and local administration. Acta Otolaryngol. 2008;128(5): 496-504.
9. Ng JH, Ho RC, Cheong CS, Ng A, Yuen HW, Ngo RY. Intratympanic steroids as a salvage treatment for sudden sensorineural hearing loss? A meta-analysis. Eur Arch Otorhinolaryngol. 2015;272:2777-2782
10. Koltsidopoulos P, et al. Intratympanic and systemic steroids for sudden hearing loss. Otology & Neurotology. 2013; 34: 771-776.