INHALANT ALLERGENS IN CENTRAL COMPARTMENT ATOPIC DISEASE
Main Article Content
Abstract
Background: Central compartment atopic disease (CCAD) is a form of diffuse primary chronic rhinosinusitis strongly associated with prolonged inhalant allergen exposure.
However, no study has yet described the common allergens associated with CCAD in the Vietnamese population. Methods: This prospective, descriptive case series included 21 patients diagnosed with CCAD and indicated for surgery at the Ear, Nose and Throat Ho Chi Minh City Hospital from March 2023 to July 2024. Results: Among 21 patients, 15 patients (71.4%) tested positive for at least one inhalant allergen, while 6 had negative results for all allergens. D.farinae was the most common allergen (52.4%), followed by B.tropicalis (42.9%), and D.pteronyssinus (38.1%). In addition, 02 cases of textile workers who were allergic to cotton dust are noted, although no antibody testing was conducted as this agent was not included in the test panel. The mean of VAS, Lund – Kennedy, Lund – Mackay scores, and the number of eosinophils in tissue did not reach statistical significance among the subgroups (patients with positive versus negative allergy test; those with varying numbers of positive airway irritants tests) (p > 0.05). Conclusions: Central compartment atopic disease is closely related to inhalant allergy and allergy treatment is essential in managing this condition. Therefore, recognizing inhalant allergies is crucial for effective treatment.
Keywords
Central compartment atopic disease, inhalant allergens
Article Details
References
2. Hamizan AW, Loftus PA, Alvarado R, et al. Allergic phenotype of chronic rhinosinusitis based on radiologic pattern of disease. Laryngoscope. Sep 2018;128(9):2015-2021. doi:10.1002/lary.27180
3. DelGaudio JM, Loftus PA, Hamizan AW, Harvey RJ, Wise SK. Central compartment atopic disease. Am J Rhinol Allergy. Jul 1 2017;31(4):228-234. doi:10.2500/ajra.2017.31.4443
4. Okubo K, Kurono Y, Ichimura K, et al. Japanese guidelines for allergic rhinitis 2020. Allergol Int. Jul 2020;69(3):331-345. doi:10.1016/j.alit.2020.04.001
5. Lee K, Kim TH, Lee SH, Kang CH, Je BK, Oh S. Predictive Value of Radiologic Central Compartment Atopic Disease for Identifying Allergy and Asthma in Pediatric Patients. Ear Nose Throat J. Mar 9 2021:145561321997546. doi:10.1177/0145561321997546
6. White LJ, Rotella MR, DelGaudio JM. Polypoid changes of the middle turbinate as an indicator of atopic disease. Int Forum Allergy Rhinol. May 2014;4(5):376-80. doi:10.1002/alr.21290
7. Abdullah B, Vengathajalam S, Md Daud MK, Wan Mohammad Z, Hamizan A, Husain S. The Clinical and Radiological Characterizations of the Allergic Phenotype of Chronic Rhinosinusitis with Nasal Polyps. J Asthma Allergy. 2020;13:523-531. doi:10.2147/JAA.S275536
8. Nguyễn Song Hào, Cao Minh Thành. XÁC ĐỊNH MỘT SỐ DỊ NGUYÊN THƯỜNG GẶP TRÊN BỆNH NHÂN VIÊM MŨI DỊ ỨNG BẰNG PANEL TEST 60 DỊ NGUYÊN TẠI BỆNH VIỆN ĐẠI HỌC Y HÀ NỘI. Tạp chí Y học Việt Nam. 12/07 2023;532(1B)doi:10.51298/vmj.v532i1B.7543
9. La Thị Kim Liên, Trần Viết Luân. Đặc điểm lâm sàng và nồng độ IgE đặc hiệu trong huyết thanh ở bệnh nhân viêm mũi dị ứng. Y học TP Hồ Chí Minh. 2019;3(23):38-43.
10. Bùi Anh Tuấn. Khảo sát sự phù nề cuốn mũi giữa ở bệnh nhân viêm mũi dị ứng. Luận văn Bác sĩ Nội trú. 2021;Trường Đại học Y khoa Phạm Ngọc Thạch
11. Tham EH, Lee AJ, Bever HV. Aeroallergen sensitization and allergic disease phenotypes in Asia. Asian Pac J Allergy Immunol. Sep 2016;34(3):181-189. doi:10.12932/AP0770
12. Pomes A, Chapman MD, Wunschmann S. Indoor Allergens and Allergic Respiratory Disease. Curr Allergy Asthma Rep. Jun 2016;16(6):43. doi:10.1007/s11882-016-0622-9
13. Quản Thành Nam, Nghiêm Đức Thuận. Đặc điểm lâm sàng, cận lâm sàng của bệnh viêm mũi dị ứng do dị nguyên bụi bông ở công nhân 2 nhà máy may đo Quốc phòng. Y dược lâm sàng 108. 2020;(7)(15)