TYMPANIC MEMBRANE ATELECTASIS (SADÉ GRADE I–II): PATHOPHYSIOLOGY, DIAGNOSTIC EVALUATION, AND TREATMENT OUTCOMES A STRUCTURED CLINICAL REVIEW

Đặng Quang Thọ1, , Phạm Thị Bích Đào2
1 Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen, Vietnam
2 Hanoi Medical University, Hanoi, Vietnam

Nội dung chính của bài viết

Tóm tắt

Objective: To synthesize the published clinical and paraclinical literature on tympanic membrane (TM) atelectasis, with particular attention to early-stage disease (Sadé grade I and II), and to summarize the evidence supporting conservative and surgical management as a basis for a planned prospective cohort study at a regional referral hospital in northern Vietnam. Methods: A structured search of PubMed/MEDLINE and Vietnamese domestic otorhinolaryngology journals was conducted for studies published between January 2010 and July 2026 addressing the pathogenesis, otoendoscopic and audiometric characteristics, tympanometric and computed-tomographic findings, or treatment outcomes of TM atelectasis or retraction pockets. Systematic reviews, narrative reviews, prospective and retrospective cohorts, and case series were eligible when they reported an extractable clinical, functional, or surgical outcome. Twenty-six clinical studies were retained for structured synthesis, supported by six additional references on pathogenesis, staging, or outcome-instrument validation. Because diagnostic criteria, staging systems, and outcome measures varied across studies, no pooled effect estimate was attempted. Results: The reviewed literature converged on eustachian tube dysfunction and sustained negative middle-ear pressure, combined with acquired weakness of the TM fibrous layer, as the principal mechanism of progressive retraction. Hearing loss and tinnitus were the most consistently reported symptoms, present in roughly four-fifths to nine-tenths of patients in the largest Vietnamese endoscopic series, while otalgia and otorrhea were less frequent and more often associated with advanced-stage disease. Pure-tone audiometry, tympanometry, the seven-item Eustachian Tube Dysfunction Questionnaire, and temporal-bone computed tomography were the diagnostic tools most consistently used to stage disease and to plan management, with CT reported to identify the site of retraction with 91.9%–97.3% accuracy against surgical findings. For grade I–II atelectasis, watchful waiting and medical treatment directed at eustachian tube dysfunction were favored as first-line management, with surgery reserved for hearing loss exceeding roughly 30 dB or failure of conservative treatment after about six months. Surgical series, most reported for more advanced disease, showed consistent improvement in the air–bone gap and generally stable anatomic outcomes, although recurrence was concentrated in higher Sadé grades. Conclusions: Grade I–II tympanic membrane atelectasis is best managed through an evaluation sequence that combines otoendoscopic staging with audiometric, tympanometric, and eustachian tube function assessment, followed by staged escalation from observation and medical therapy to minimally invasive ventilation or reinforcement surgery when disease progresses. Vietnamese data, particularly from referral centres outside major cities, remain limited, and a structured cohort describing the clinical, paraclinical, and treatment-outcome profile of grade I–II disease would address a clear gap in the regional literature. Keywords: tympanic membrane atelectasis; retraction pocket; eustachian tube dysfunction; Sadé classification; cartilage tympanoplasty; ventilation tube; air–bone gap.

Chi tiết bài viết

Tài liệu tham khảo

1. Iannella G, Pace A, Greco A, et al. Endoscopic ear surgery in the treatment of chronic otitis media with atelectasis. Eur Arch Otorhinolaryngol. 2024;281(12):6283-6291. doi:10.1007/s00405-024-08845-0.
2. Bayoumy AB, Veugen CCAFM, van der Veen EL, Bok JM, de Ru JA, Thomeer HGXM. Management of tympanic membrane retractions: a systematic review. Eur Arch Otorhinolaryngol. 2022;279(2):723-737. doi:10.1007/s00405-021-06719-3.
3. Urík M, Tedla M, Hurník P. Pathogenesis of retraction pocket of the tympanic membrane - a narrative review. Medicina (Kaunas). 2021;57(5):425. doi:10.3390/medicina57050425.
4. Canali I, Rosito LPS, Elias CCL. Retraction pockets and adhesive otitis media. In: Goycoolea MV, da Costa SS, de Souza C, Paparella MM, eds. Textbook of Otitis Media: The Basics and Beyond. Springer International Publishing; 2023:395-406.
5. Thuy NL. Endoscopic clinical forms of tympanic membrane atelectasis at Thai Nguyen University of Medicine Hospital. J Sci Technol (Thai Nguyen Univ). 2014;134:163-168 [in Vietnamese].
6. Chhoa KH, Ho LHN, Pham TT. Clinical and paraclinical characteristics and endoscopic surgical outcomes of localized tympanic membrane atelectasis at Can Tho ENT Hospital, 2022-2024. Can Tho J Pharm Med Sci. 2024:275-280. doi:10.58490/ctump.2024i77.2744 [in Vietnamese].
7. Thanh DD. Tympanic membrane status after ventilation tube extrusion in patients treated for otitis media with effusion at the National ENT Hospital. Vietnam Med J. 2024;1:183-187 [in Vietnamese].
8. Bayoumy AB, Veugen C, van Rijssen LB, Yung M, Bok JM. The natural course of tympanic membrane retractions in the posterosuperior quadrant of pars tensa: a watchful waiting policy. Otol Neurotol. 2021;42(9):e50-e59. doi:10.1097/mao.0000000000002834.
9. Zeng J, et al. A deep learning approach to the diagnosis of atelectasis and attic retraction pocket in otitis media with effusion using otoscopic images. Eur Arch Otorhinolaryngol. 2023;280(4):1621-1627. doi:10.1007/s00405-022-07632-z.
10. Monga U. Role of otoendoscopy in evaluation of tympanic membrane retraction - a new perspective. Online J Health Allied Sci. 2024;23:1-4.
11. Canali I, Schmidt Rosito LP, Longo VD, de Andrade Águas JV, da Costa SS. Comparative analysis of moderate and severe tympanic membrane retractions in children and adults. Int J Pediatr Otorhinolaryngol. 2021;147:110784. doi:10.1016/j.ijporl.2021.110784.
12. Bright T, et al. Evaluating the inclusion of tympanometry in population-based surveys of hearing loss. J Laryngol Otol. 2022;136(9):839-847. doi:10.1017/S0022215122001190.
13. Tuan TA. Value of temporal-bone computed tomography in the evaluation of the tympanic membrane in atelectatic ears. Vietnam Med J. 2021;500. doi:10.51298/vmj.v500i2.393 [in Vietnamese].
14. Lai TH, Vu DL, Le VK. Correlation between mastoid pneumatization pattern and middle-ear ventilation status on computed tomography in atelectatic ears. Vietnam J Radiol Nucl Med. 2020:4-10. doi:10.55046/vjrnm.40.178.2020 [in Vietnamese].
15. Ráth G, et al. Transmeatal excision of pars tensa retraction pockets with simultaneous ventilation tube insertion in children: a prospective study. Eur Arch Otorhinolaryngol. 2011;268(11):1549-1556. doi:10.1007/s00405-011-1521-2.
16. Kalra VK, Yadav SPS, Verma M, Singh B, Goel A. Treatment of tympanic membrane retraction pockets by excision and cartilage tympanoplasty: a prospective study. Indian J Otolaryngol Head Neck Surg. 2018;70(3):392-394. doi:10.1007/s12070-018-1388-2.
17. Immordino A, Sireci F, Lorusso F, Martines F, Dispenza F. The role of cartilage-perichondrium tympanoplasty in the treatment of tympanic membrane retractions: systematic review of the literature. Int Arch Otorhinolaryngol. 2022;26(3):e499-e504. doi:10.1055/s-0042-1742349.
18. Immordino A, et al. Mastoidectomy in surgical procedures to treat retraction pockets: a single-center experience and review of the literature. Eur Arch Otorhinolaryngol. 2023;280(3):1081-1087. doi:10.1007/s00405-022-07573-7.
19. Lou Z, Lou Z, Sun J, Chen Z, Yin S. Microwave ablation eustachian tuboplasty: a preliminary investigation with long-term follow-up. J Otolaryngol Head Neck Surg. 2021;50:39. doi:10.1186/s40463-021-00520-2.
20. Dinh LC. Surgical treatment outcomes of tympanic membrane atelectasis at the ENT Department, Bach Mai Hospital. J Med Res (Hanoi Med Univ). 2013;82(2):71-77 [in Vietnamese].
21. Pisy S. Outcomes of endoscopic attico-antrostomy combined with transcanal middle-ear reconstruction in Thai Nguyen. Vietnam J Otorhinolaryngol. 2023;68-59:19-26 [in Vietnamese].
22. Pham TT, Ho MP, Ho LHN. Efficacy of endoscopic surgery in the treatment of stage-4 tympanic membrane atelectasis. Vietnam Med J. 2023;529. doi:10.51298/vmj.v529i1.6239 [in Vietnamese].
23. American Speech-Language-Hearing Association. Type, Degree, and Configuration of Hearing Loss. ASHA; 2023.
24. Kjær Krogshede S, Kirchmann M, Jørkov APS, Glad H. Balloon dilation of the eustachian tube: a randomized controlled trial with 6 months follow-up. J Int Adv Otol. 2022;18(6):501-506. doi:10.5152/iao.2022.21198.
25. Alzahrani M, Saliba I. Tympanic membrane retraction pocket staging: is it worthwhile? Eur Arch Otorhinolaryngol. 2014;271(6):1361-1368. doi:10.1007/s00405-013-2644-4.
26. Subashini P, S S. Differential tympanic membrane retraction: a comprehensive study. Int J Health Sci. 2022;6:11316-11328.
27. Hang NT. Clinical and paraclinical characteristics and preliminary treatment outcomes of tympanic membrane atelectasis at Vinh City General Hospital, 2024. J Med Pharm (Vinh Med Univ). 2024;1:31-36 [in Vietnamese].
28. Chibou D, Romdhane N. Tympanic membrane retractions in children: clinical features and surgical outcomes. Orig Artic. 2021;46:58-62.
29. Jayadevan PJ, Raj P, Anand V, Singh K. Prevalence of eustachian tube dysfunction in patients with allergic rhinitis: an observational cross-sectional study. 2024;26:253-257. doi:10.4103/jmms.jmms_109_23.
30. Shukla N, Singh DK, Adhaulia G, Sengar M. Clinical manifestations of attic retraction pockets. Orig Res Artic. 2024;6:1043-1045.
31. Canali I, Rosito LPS, Longo VD, da Costa SS. Critical analysis of moderate and severe retractions in the pars tensa and pars flaccida of the tympanic membrane. Braz J Otorhinolaryngol. 2023;89(1):114-121. doi:10.1016/j.bjorl.2021.10.005.
32. McCoul ED, Anand VK, Christos PJ. Validating the clinical assessment of eustachian tube dysfunction: the eustachian tube dysfunction questionnaire (ETDQ-7). Laryngoscope. 2012;122(5):1137-1141. doi:10.1002/lary.23223.